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POSTER PRESENTATIONS

Poster Session I - Monday, 31 October 2016

 

M1. CEREBROVIZ: AN R PACKAGE FOR ANATOMICAL VISUALIZATION OF SPATIOTEMPORAL BRAIN DATA

Ethan Bahl1, Tanner Koomar1, Jacob Michaelson1

1The University of Iowa

 

M2. RARE VARIANT DETECTION IN COMPLEX DISORDERS USING THE BIRTHDAY MODEL

Yael Berstein1, Shane McCarthy2, Melissa Kramer1, Peter Zandi3, Fernando Goes3, James Potash4, Richard McCombie1

1Cold Spring Harbor Laboratory, 2Regeneron Pharmaceuticals, Inc, 3Johns Hopkins University, 4The University of Iowa Carver College of Medicine

 

M3. A BAYESIAN APPROACH TO QUANTIFY ENRICHMENT IN GWAS TEST STATISTICS

Jon Alm Eriksen1, Francesco Bettella1, Wesley Thompson2, Yunpeng Wang3, Aree Witoelar1, Olav Smeland4, Oleksandr Frei1, Srdjan Djurovic4, Anders Dale2, Ole Andreassen1

1University of Oslo, 2Univerisity of California, San Diego, 3NORMENT, University of Oslo and Institute of Biological Psychiatry, St. Hans hospital, Denmark, 4Oslo University Hospital

 

M4. MULTI-STATE SURVIVAL ANALYSIS OF MULTI-PSYCHIATRY DISORDERS

Yunpeng Wang1, Ole Andreassen2, Andrew Schork3, Thomas Werge4, Wesley Thompson3

1NORMENT, University of Oslo and Institute of Biological Psychiatry, St. Hans Hospital, Denmark., 2University of Oslo, 3University of California, San Diego, 4Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services – Copenhagen

 

M5. THE USE OF GENOMIC INFORMATION IN MEDICAL PRACTICE: A SURVEY ON PEOPLE’S KNOWLEDGE, EXPECTATIONS, AND FEARS

Laura Flatau1, Nadine Umbach2, Ulrich Sax2, Tim Beissbarth3, Gunnar Duttge4, Mark Schweda5, Thomas Schulze6

1University of Munich, 2Department of Medical Informatics Göttingen, 3Department of Medical Statistics ,University of Göttingen, 4Center for Medical Law, University of Goettingen, 5Department of Medical Ethics, University of Göttingen, 6Institute of Psychiatric Phenomics and Genomics (IPPG); Ludwig-Maximilians-University Munich, Munich, Germany

 

M6. PRESYMPTOMATIC GENETIC COUNSELING IN FRONTOTEMPORAL DEMENTIA/AMYOTROPHIC LATERAL SCLEROSIS: A POTENTIAL MODEL FOR GENETIC TESTING IN NEURODEGENERATIVE DISORDERS

Weiyi Mu1

1Johns Hopkins University

 

M7. ACHIEVING THE PROMISE OF TRANSLATIONAL GENOMICS IN PSYCHIATRIC CARE

Bradley Evanoff1, Laura Bierut1

1Washington University School of Medicine in St. Louis

 

M8. FRAMEWORK FOR THE RETURN OF RESULTS TO PSYCHIATRIC GENOMICS RESEARCH PARTICIPANTS: WHAT SHOULD BE OFFERED?

Gabriel Lazaro-Munoz1, Martilias S. Farrell1, Eric T. Ward1, Maria D. Iglesias de Ussel2, Dawn M. Filmyer3, Genna Finkel3, James J. Crowley2, Rita A. Shaughnessy3,4, Richard C. Josiassen3,4, Eric T. Juengst1, Patrick Sullivan1

1University of North Carolina at Chapel Hill School of Medicine, 2Center for Psychiatric Genomics, University of North Carolina, Chapel Hill, NC, USA, 3Translational Neuroscience LLC, 4Drexel University College of Medicine

 

M9. SEX-SPECIFIC FOXP1 AND FOXP2 EXPRESSION IN THE DEVELOPING MOUSE BRAIN AND ITS IMPACT ON VOCAL COMMUNICATION

G.A. Rappold1, Henning Fröhlich1, Rafiullah Rafiullah1, Nathalie Schmitt1, Sonja Abele1

1University of Heidelberg

 

M10. ISOFORM DEPENDENT FUNCTIONS OF AUTS2 DURING NEURONAL DIFFERENTIATION

Galya Rothkoff1, Marina Reisman1, Nitzan Tal1, Odem Shani1, Malka Nissim-Rafinia1, Eran Meshorer1, Sagiv Shifman1

1The Hebrew University of Jerusalem

 

M11. DE NOVO GENIC MUTATIONS AMONG A CHINESE AUTISM SPECTRUM DISORDER COHORT

Tianyun Wang1, Hui Guo1, Bo Xiong2, Holly Stessman2, Kun Xia1, Evan Eichler2

1The State Key Laboratory of Medical Genetics, 2Department of Genome Sciences, University of Washington

 

M13. CONTRIBUTION OF THE 14-3-3 GENE FAMILY TO AUTISM SPECTRUM DISORDER

Bru Cormand1, Bàrbara Torrico1, Sadaf Ghorbani2, Noèlia Fernàndez-Castillo1, Laura Pineda1, Amaia Hervás3, Barbara Franke4, Jan Buitelaar5, Christine Freitag6, Andreas Reif7, Isabel Rueda8, Rune Kleppe2, Jan Haavik2, Claudio Toma9

1Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, 2Department of Biomedicine, University of Bergen, Norway, 3Child and Adolescent Mental Health Unit, Hospital Universitari Mútua de Terrassa, Spain, 4Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands, 5Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands, 6Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe-University Frankfurt am Main, Frankfurt am Main, Germany, 7Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt am Main, Germany, 8Developmental Disorders Unit (UETD), Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain, 9Neuroscience Research Australia (NeuRA)

 

M14. SPECIFIC ASD PHENOTYPES ARE MODULATED BY DISTINCT GENETIC VARIANTS CONVERGING AT NETWORK LEVEL

Andreas G. Chiocchetti1, Regina Waltes1, Denise Haslinger1, Silvia Lindlar1, Sabine Klauck1, Eftichia Duketis1, Michael Sachse1, Anette Voran2, Monica Biscaldi3, Martin Schulte-Rüther4, Stephan Kupferschmid5, Sven Cichon6, Markus Nöthen7, Jörg Ackermann8, Ina Koch8, Christine M. Freitag1

1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, Frankfurt am Main, 2Department of Child and Adolescent Psychiatry, Saarland University, Homburg, 3Department of Child and Adolescent Psychiatry, University Hospital Freiburg, 4Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen, 5University Hospital of Child and Adolescent Psychiatry, University of Bern, Bern, 6Division of Medical Genetics, University of Basel, Basel, 7Institute of Human Genetics, University of Bonn, Bonn, 8Molecular Bioinformatics, Institute of Computer Science, Goethe University Frankfurt, Frankfurt am  Main

 

M15. OVERLAPPING PATTERN OF GENETIC ASSOCIATIONS OF ALZHEIMER’S DISEASE AND SCHIZOPHRENIA MEDIATED BY COGNITIVE ENDOPHENOTYPES GENES

Vadim Stepanov1, Anna Bocharova1, Andrey Marusin1

1Research Institute for Medical Genetics

 

M15A. EFFECT OF APOE EPSILON4 ON AGE AT ONSET IN ALZHEIMER’S DISEASE: COMPARISON OF A BRAZILIAN SAMPLE WITH AN ITALIAN SAMPLE

Vincenzo de Luca1, Jose Araujo2, Maria Aparecida Camargos Bicalho3,

Renan Souza4, Gianfranco Spalletta5

1Centre for Addiction and Mental Health, 2CAMH, 3Departamento de Clínica médica UFMG, 4Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 5IRCCS Santa Lucia Foundation

M16. EPIGENETIC AGE ACCELERATION ASSESSED IN WHITE-MATTER INTEGRITY: TOWARDS A BIOMARKER OF SUCCESSFULLY BRAIN AGING

Karen Hodgson1, Melanie Carless2, Joanne Curran2, Emma Sprooten3, Emma Knowles4, Samuel Mathias5, Nailin Yao4, Harald Göring6, Rene Olvera7, Peter Fox7, Laura Almasy6, Ravi Duggirala6, John Blangero6, David Glahn8

1Yale University School of Medicine, 2Texas Biomedical Research Institute, 3Department of Psychiatry, School of Medicine, Yale University, 4Yale University, 5Yale School of Medicine, 6University of Texas Rio Grande Valley, 7University of Texas Health Science Center San Antonio, 8Yale University and Olin Neuropsychiatric Research Center

 

M17. POTENTIAL BRAIN MORPHOLOGY INSTABILITY FEATURES MEDIATING THE ASSOCIATION BETWEEN GENOME-WIDE HOMOZYGOSITY AND ALTERED NEUROCOGNITION

Aldo Córdova-Palomera1, Francesco Bettella2, Yunpeng Wang3, Nhat Trung Doan4, Dag Alnæs4, Torgeir Moberget4, Tobias Kaufmann4, Ida Sonderby5, Ingrid Agartz2, Ole Andreassen2, Lars Tjelta Westlye4

1Oslo University Hospital, 2University of Oslo, 3NORMENT, University of Oslo and Institute of Biological Psychiatry, St. Hans hospital, Denmark, 4NORMENT, 5NORMENT, KG Jebsen Centre for Psychosis Research, Oslo

 

M18. AN EXPLORATORY STUDY OF THE GENETIC RELATIONSHIPS BETWEEN PLASMA-BASED MEASURES OF INFLAMMATION AND BRAIN ANATOMY

Samuel Mathias1, Emma Knowles2, Joanne Curran3, Harald Goring4, Rene Olvera5, Peter Fox5, Ravi Duggirala3, Laura Almasy3, John Blangero6, David Glahn7

1Yale School of Medicine, 2Yale University, 3University of Texas Rio Grande Valley, 4South Texas Diabetes and Obesity Institute, 5University of Texas Health Science Center San Antonio, 6University of Texas Rio Grande Valley School of Medicine, 7Yale University and Olin Neuropsychiatric Research Center

 

M19. DOES THE FREQUENCY OF ENZYMATIC REPLACEMENT THERAPY INFLUENCE PATIENTS’ LEVEL OF ADAPTIVE FUNCTIONING?

Stefania Caviglia1, Ambra Bottari1, Paola Bazzu1, Federica Deodato1, Roberta Taurisano1, Ilaria Tondo1

1Bambino Gesù Children's Hospital

 

M20. TRAIT-SPECIFIC PATTERNS OF COMMON GENETIC FACTORS INFLUENCE SOCIAL-COMMUNICATION DIFFICULTIES AND ADHD SYMPTOMS DURING CHILD AND ADOLESCENT DEVELOPMENT

Beate St Pourcain1, Lindon Eaves2, David M Evans3, Evie Stergiakouli4, Simon E Fisher5, Susan M Ring4, Gregory Carey6, Davey Smith George4

1Language and Genetics Department, Max Planck Institute for Psycholinguistics, The Netherlands ; MRC Integrative Epidemiology Unit (MRC IEU), University of Bristol, UK, 2Department of Human and Molecular Genetics, Institute for Psychiatric and Behavioral Genetics, Commonwealth University School of Medicine, Richmond, Virginia, USA, 3MRC Integrative Epidemiology Unit (MRC IEU), University of Bristol, UK; University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Australia, 4MRC Integrative Epidemiology Unit (MRC IEU), University of Bristol, UK; School of Social and Community Medicine, University of Bristol, UK, 5Language and Genetics Department, Max Planck Institute for Psycholinguistics, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, 6Department of Psychology, University of Colorado CB 345, Boulder CO, USA

 

M21. THE ROLE OF THE GENETIC SEGMENTS 5-HTTLPR AND MAOA IN MODERATING THE ASSOCIATION BETWEEN DEVELOPMENTAL ENVIRONMENT AND SOCIAL AND EMOTIONAL ABILITIES

Yoav Kohn1,2, Liat Sheffer-Matan2, Uri Guy1, Anat Guy3, Galya Monderer4, Sagiv Shifman4

1Jerusalem Mental Health Center, Eitanim Psychiatric Hospital, Israel 2Hebrew University-Hadassah School of Medicine, Jerusalem, Israel, 3School of Behavioral Science, College of Management, Rishon LeZion, Israel, 4Department of Genetics, The Life Sciences Institute, Hebrew University, Jerusalem, Israel

 

M22. COMMON GENETIC VARIANTS ASSOCIATED WITH PERSONALITY DIMENSIONS IN THE HEIDELBERG COHORT STUDY OF THE ELDERLY (HEIDE)

Urs Heilbronner1, Till F. M. Andlauer2, Sergi Papiol1, Monika Budde1, Jana Strohmaier3, Fabian Streit3, Josef Frank3, Manfred Amelang4, Til Stürmer5, Bertram Müller-Myhsok2, Marcella Rietschel3, Thomas G. Schulze1

1Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 2Max Planck Institute of Psychiatry, Munich, Germany, 3Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany, 4Department of Psychology, University of Heidelberg, Germany, 5Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, USA

 

M23. ENRICHMENT OF GENETIC VARIANTS ASSOCIATED WITH CLINICAL RESPONSE TO LITHIUM IN CIRCADIAN CLOCK SYSTEM GENE SETS

Urs Heilbronner1, Sergi Papiol2, The International Consortium on Lithium Genetics (ConLiGen)1, Michael McCarthy3, Caroline Nievergelt4, Enda Byrne5, Thomas G. Schulze1

1Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 2Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich; Molecular and Behavioral Neurobiology, Department of Psychiatry, Medical Center of the University of Munich, Germany, 3VA San Diego Healthcare System; Department of Psychiatry, University of California San Diego, 4Department of Psychiatry, University of California San Diego, 5Queensland Brain Institute, The University of Queensland

 

M24. EPIGENETIC DIFFERENCES IN MONOZYGOTIC TWINS DISCORDANT FOR MAJOR DEPRESSIVE DISORDER

Fraser Harris1, Karim Malki2, Elena Koritskaya3, Kevin Bryson3, Mark Herbster3, Maria Grazia Tosto2

1King's College London, 2MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King’s College London, 3Department of Computer Science, University College London

 

M25. INVESTIGATION OF RELATIONSHIPS BETWEEN BIPOLAR DISORDER PHENOTYPES AND GENOME-WIDE SIGNIFICANT LOCI FROM PGC2 SCHIZOPHRENIA

Ganna Leonenko1, Judith Allardyce1, Liz Forty2, Sarah Knott1, Nicholas Craddock2, Michael Owen3, Michael O'Donovan2, Ian Jones2, Valentina Escott-Price3

1Cardiff University School of Medicine, 2Cardiff University, 3MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University

 

M26. WHOLE GENOME SEQUENCING TO IDENTIFY DE NOVO MUTATIONS IN BIPOLAR DISORDER

Fernando Goes1, Mehdi Pirooznia1, Martin Tehan1, Paula Wolyniec1, John McGrath1, Gerald Nested1, Ann Apulver1

1Johns Hopkin University                                                  

 

M27. EPIGENETIC ALTERATIONS OF THE GLIA CELL-DERIVED NEUROTROPHIC FACTOR AND RESPONSE TO ELECTROCONVULSIVE STIMULATION

Alexandra Kleimann1, Meraj Neyazi1, Wiebke Theilmann2, Mathias Rhein1, Wolfgang Löscher3, Stefan Bleich1, Claudia Brandt3, Helge Frieling1
1Hannover Medical School, Germany, 2University of Helsinki, Neuroscience Center, Finland, 3University of Veterinary Medicine, Department of Pharmacology- Toxicology- and Pharmacy, Hannover, Germany

 

M28. POLYGENIC RISK FOR BIP, MDD, AND SCZ IN ANDALUSIAN MULTIPLEX FAMILIES

Till Andlauer1, Jose Guzman Parra2, Jana Strohmaier3, Fabian Streit3, Josef Frank3, Andreas J. Forstner4, Stefan Herms5, Stephan Ripke6, Bipolar Disorder Working Group7, Major Depressive Disorder Working Group7, Bertram Müller-Myhsok8, Sven Cichon9, Fermín Mayoral Cleries10, Markus Nöthen11, Marcella Rietschel3

1Max Planck Institute of Psychiatry, 2Hospital Universitario Carlos Haya, 3Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany, 4University of Bonn, Germany, 5Human Genomics Research Group, Department of Biomedicine, University of Basel, Switzerland; Department of Genomics, Life and Brain Center, University of Bonn, Germany, 6Analytic and Translational Genetics Unit, Massachusetts General Hospital, 7Psychiatric Genomics Consortium, 8Max Planck Institute of Psychiatry; Munich Cluster for Systems Neurology (SyNergy), Munich; Institute of Translational Medicine University of Liverpool, Liverpool, 9Division of Medical Genetics, University of Basel, 10Malaga Regional University Hospital, Biomedicine Institute of Malaga, Malaga, Spain, 11Institute of Human Genetics, University of Bonn, Germany

 

M29. PHENOTYPIC TRAITS OF BIPOLAR DISORDER PREDICTED BY SCHIZOPHRENIA ASSOCIATED SNPS IN ROMANIAN BIPOLAR I PATIENTS. PRELIMINARY RESULTS

Maria Grigoroiu-Serbanescu1, Tim Bigdeli2, Johan Thygesen3, Stefan Herms4, Andreas Forstner5, Markus Noethen6, Andrew McQuillin3

1Alexandru Obregia Clinical Psychiatric Hospital, Psychiatric Genetics Research Unit, Medical University, Bucharest, Romania, 2Virginia Commonwealth Univ, Dept. Psychiatry, Richmond, VA, USA, 3University College London, Dept. Psychiatry, London, UK, 4University of Basel,  Division of Medical Genetics, Basel, Switzerlandd, 5Institute of Human Genetics, Univ. Bonn, Bonn, Germany, 6Institute of Human Genetics, University of Bonn, Germany

 

M30. HIGH HERITABILITY OF TELOMERE LENGTH IN FAMILIES WITH BIPOLAR DISORDER

Daniela Martinez1, Vincent Millischer2, Leandro Michelon3, Caroline Camilo3, Helena Brentani3, Nubia Esteban4, José Krieger4, Alexandre Pereira4, Catharina Lavebratt2, Martin Schalling2, Homero Vallada2

1Univesity of Sao Paulo Medical School, 2Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 3Department and Institute of Psychiatry (LIM 23), University of São Paulo Medical School, São Paulo, SP, Brazil, 4Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo Medical School, São Paulo, SP, Brazil

 

M31. GENE EXPRESSION IN BLOOD OF CHILDREN AND ADOLESCENTS: INFLUENCE OF ENVIRONMENTAL STRESSORS ON MAJOR DEPRESSIVE DISORDER

Leticia Spindola1, Pedro Pan1, Patricia Moretti1, Vanessa Ota2, Marcos Santoro1, Hugo Cogo-Moreira1, Ary Gadelha1, Giovanni Salum Junior3, Gisele Manfro4, Jair Mari1, Helena Brentani5, Rodrigo Grassi-Oliveira6, Elisa Brietzke1, Euripedes Constantino Miguel7, Luis Rohde8, João Sato9, Rodrigo Bressan1, Sintia Belangero1

1Federal University of Sao Paulo, 2UNIFESP, 3Hospital de Clinicas de Posto Alegre, 4UFGRS, 5University of São Paulo Medical School, 6Pontifical Catholic University of Rio Grande do Sul, 7University of Sao Paulo, 8Federal University of Rio Grande do Sul, 9Universidade Federal do ABC

 

M32. MITOCHONDRIAL GENETIC RISK IN OCD AND RELATED SUBPHENOTYPES

James L. Kennedy1, Vanessa Gonçalves1, Gwyneth Zai2, Margaret (Peggy) Richter3

1Centre for Addiction and Mental Health, 2University of Toronto, 3Sunnybrook Health Sciences Centre

 

M33. GENETIC VARIATION AND EPIGENETIC MODIFICATION OF SKA2: ASSOCIATIONS WITH OBSESSIVE-COMPULSIVE DISORDER DISEASE RISK AND SYMPTOM SEVERITY

James L. Kennedy1, Amanda Lisoway1, Clement C. Zai1, Gwyneth Zai2, Akhil Nair1, Sasha Ebrahimi1, Arun K. Tiwari1, Art Petronis3, Zachary Kaminsky4, Margaret (Peggy) Richter5

1Centre for Addiction and Mental Health, 2University of Toronto, 3Centre for Addiction and Mental Health, and University of Toronto, 4Johns Hopkins University, 5Sunnybrook Health Sciences Centre

 

M34. ECG ALTERATIONS ASSOCIATED WITH PSYCHOTROPIC DRUG USE IN CLINICAL SETTINGS: CLINICAL AND GENETIC PREDICTORS

Alessandro Serretti1, Chiara Fabbri2, Giuseppe Boriani3, Igor Diemberger4, Maria Giulia Filippi5, Gloria Ravegnini5, Patrizia Hrelia5, Alessandro Minarini6, Diego Albani7, Gianluigi Forloni7, Sabrina Angelini5

1Institute of Psychiatry, 2Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy, 3Department of Cardiology, Modena University Hospital, University of Modena and Reggio Emilia, Italy 4Department of Specialist, Diagnostic and Experimental Medicine, University of Bologna, Italy, 5Department of Pharmacy and Biotechnology, University of Bologna, Italy, 6Department of Diagnostic, Clinical and Public Health Medicine, Section of Psychiatry, University of Modena and Reggio Emilia, Modena, Italy, 7IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy

 

M35. IDENTIFICATION OF GENETIC LOCI FOR TREATMENT RESPONSE OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS ON EMPIRICALLY DEFINED DEPRESSION SYNDROMAL FACTORS

Po-Hsiu Kuo1, Yi-Ting Chen2, Chung-Feng Kao2, Albert C. Yang3, Shih-Jen Tsai3, Yu-Li Liu4

1Institute of Epidemiology and Preventive Medicine, NTU, 2Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, 3Division of Psychiatry, National Yang-Ming University, Taipei, Taiwan, 4Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan

 

M36. CO-EXPRESSED TRANSCRIPTOME ANALYSES REVEAL CONSISTENT BIOLOGICAL PATHWAYS FOR MANIC EPISODE

Ya-Chin Lee1, Ming-Chyi Huang2, Yu-Lin Chao3, Ming-Hsien Hsieh4, Hsi-Chung Chen4, Wen-Yin Chen2, Tzu-Pin Lu1, Po-Hsiu Kuo5

1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, 2Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan, 3Tzu Chi general hospital, 4Department of Psychiatry, National Taiwan University Hospital, 5Institute of Epidemiology and Preventive Medicine, NTU

 

M37. RNA-SEQUENCING OF BIPOLAR DISORDER PATIENTS LYMPHOBLASTOID CELL LINES IMPLICATES A NOVEL NEUROTROPHIC FACTOR IN THE EFFICACY OF LITHIUM AS MOOD STABILIZING DRUG

Elena Milanesi1, Irena Voinsky2, Adva Hadar2, Carlo Maj1, John R. Kelsoe3, Tatyana Shekhtman3, Peter Zandi4, Fernando Goes4, James B. Potash5, Michael Greshovits6, Shlomit Gilad6, Massimo Gennarelli1, Thomas G. Schulze7, David Gurwitz8

1Genetics Unit, Centro San Giovanni di Dio Fatebenefratelli, Italy, 2Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel, 3Department of Psychiatry, University of California San Diego, La Jolla, California, 92093, USA, 4Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21218, USA, 5Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa., 6The Nancy & Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel, 7Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany, 8Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University Israel

 

M38. PHARMACOGENETICS OF DISP1 GENETIC VARIANT IN OBSESSIVE-COMPULSIVE DISORDER

Clement Zai1, Gwyneth Zai2, Amanda Lisoway1, Karen Wigg3, Danning Zhang1, Natalie Freeman1, Daniel Mueller1, James L. Kennedy1, Margaret (Peggy) Richter3

1Centre for Addiction and Mental Health, 2University of Toronto, 3Sunnybrook Health Sciences Centre

 

M39. INVESTIGATING THE ROLE OF TREATABLE GENETIC DISEASES IN SCHIZOPHRENIA AND BIPOLAR DISORDER POPULATIONS AND ITS CLINICAL DIAGNOSTIC IMPACT

Clement Zai1, Venuja Sriretnakumar1, Ricardo Harripaul1, Kirti Mittal1, James L. Kennedy1, Joyce So1

1Centre for Addiction and Mental Health

 

M40. EFFECT OF CHRONIC TREATMENT WITH PSYCHIATRIC MEDICATIONS ARIPIPRAZOLE AND RILUZOLE ON DNA METHYLATION PROFILES IN THE RAT STRIATUM AND PREFRONTAL CORTEX

Luca Pagliaroli1, Francesca Rizzo2, Piroska Devay3, Pal Szabo4, Andrea Ludolph5, Tobias Boeckers6, Csaba Barta7, Tamas Aranyi3

1Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary, 2Department of Child and Adolescence Psychiatry/Psychotherapy; Institute of Anatomy and Cell Biology, University of Ulm, Germany, 3Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, 4Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, 5Department of Child and Adolescence Psychiatry/Psychotherapy, University of Ulm, Germany, 6Institute of Anatomy and Cell Biology, University of Ulm, Germany, 7Semmelweis University

 

M41. PLEIOTROPIC EFFECTS OF SCHIZOPHRENIA AND COGNITIVE LOCI: A META-ANALYTIC APPROACH

Max Lam1, Richard Keefe2, Jian Jun Liu3, Jimmy Lee1

1Institute of Mental Health, 2Duke University Medical Center, 3Genome Institute Singapore

 

M42. USING POLYGENIC SCORES BASED ON SCHNEIDERIAN FIRST RANK SYMPTOMS TO CHARACTERIZE DISEASE TRAJECTORIES IN SEVERE MENTAL ILLNESSES

Heike Anderson-Schmidt1, Sergi Papiol2, Till F. M. Andlauer3, Urs Heilbronner4, Monika Budde4, Janos Kalman5, Franziska Degenhardt6, Markus Nöthen7, Jana Strohmaier8, Josef Frank8, Stephanie Witt8, Bertram Müller-Myhsok9, Peter Falkai10, Marcella Rietschel8, Thomas G. Schulze11

1University Medical Centre Goettingen, 2Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich; Molecular and Behavioral Neurobiology, Department of Psychiatry, Medical Center of the University of Munich, Germany, 3Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry Munich, 4Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 5Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, 6Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany, 7Institute of Human Genetics, University of Bonn, Germany, 8Central Institute of Mental Health, 9Max Planck Institute of Psychiatry;Munich Cluster for Systems Neurology (SyNergy), Munich; Institute of Translational Medicine University of Liverpool, Liverpool, 10Molecular and Behavioral Neurobiology, Department of Psychiatry, Ludwig Maximillian University, Munich, Germany, 11Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany

 

M43. COMORBID MEDICAL CONDITIONS IN INDIVIDUALS WITH MAJOR PSYCHIATRIC DISORDERS

Margarita Rivera1, Paula Rovira2, Blanca Gutierrez3, Ana Ching-López4, Esther Molina5, María Victoria Martín-Laguna6, Inmaculada Ibanez-Casas6, Kathryn McKenney6, Isabel Ruiz-Pérez7, Miguel Rodríguez-Barranco8, Jorge Cervilla4

1King's College London, 2Psychiatric Genetics Unit, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Spain, 3University of Granada, 4Departamento de Psiquiatría e Instituto de Neurociencias, Universidad de Granada, Granada, Spain, 5Departamento de Enfermería, Universidad de Sevilla, Sevilla, Spain, 6CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental)-Universidad de Granada, Granada, Spain, 7CIBER de Epidemiología y Salud Pública (CIBERESP), Granada, Spain, 8Andalusian School of Public Health, Granada, Spain.

 

M44. INVESTIGATION OF GENETIC VARIANTS WITHIN GENES TARGETS OF ANTIPSYCHOTIC RESPONSE AND THEIR SIGNAL CASCADE IN SCHIZOPHRENIA AND ANTIPSYCHOTIC RESPONSE

Marco Calabrò1, Stefano Porcelli2, Concetta Crisafulli1, Antonella Sidoti1, Tae-Youn Jun3, Soo-Jung Lee3, Changsu Han4, Ashwin Paktar5, Prakash Masand6, Chi-un Pae3, Alessandro Serretti2

1University of Messina, 2University of Bologna, 3Catholic University of Korea, Seoul, 4Korea University, 5Duke University Medical Center, 6Global Medical Education, NY

 

M45. EXPLORING THE EFFECTS OF MUSCARINIC M1 RECEPTOR SEQUENCE VARIATION ON EXECUTIVE FUNCTIONING IN SCHIZOPHRENIA AND HEALTHY CONTROLS

Sean Carruthers1, Vanessa Cropley2, Caroline Gurvich3, Kiymet Bozaoglu4, Christos Pantellis5, Susan Rossell6

1Swinburne University of Technology, 2Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health; Department of Psychiatry, The University of Melbourne, 3Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia, 4Baker IDI Heart and Diabetes Institute, Melbourne, Australia, 5Melbourne Neuropsychiatry Centre, The University of Melbourne & Melbourne Health, Melbourne, Australia, 6Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia; Brain and Psychological Sciences Research Centre (BPsyC), Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia; St Vincent’s Mental Health, Melbourne, Australia

 

M46. BIOMARKERS IN SCHIZOPHRENIA: A FOCUS ON BLOOD BASED THERANOSTICS

Sosin Dmitriy1, Nasyrova Regina1, Taraskina Anastasia2, Ershov Evgeny3, Sosina Kristina1, Zabotina Anna4, Grunina Maria5, Pchelina Maria6, Krupitsky Evgeny1

1Saint Petersburg Bekhterev Research Psychoneurological Institute, 2Saint Petersburg Bekhterev Research Psychoneurological Institute; First Saint Petersburg Pavlov State medical University; National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, 3Saint Petersburg Psychiatric Hospital №1 named after P.P. Kaschenko, 4First Saint Petersburg Pavlov State medical University; National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, 5National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, 6First Saint Petersburg Pavlov State medical University

 

M47. WHOLE EXOME SEQUENCING OF AFFECTED INDIVIDUALS FROM LARGE CONSANGUINEOUS PEDIGREES WITH PSYCHOTIC/AFFECTIVE DISORDERS FROM PAKISTAN

Qin He1, Ilyass Hajji2, Daniel Jimenez2, Souhila Benbetka2, Amelie Johnson2, Alexandre Dionne-Laporte3, Dan Spiegelman3, Ridha Joober4, Marie-Pierre Dubé5, Lynn DeLisi6, Guy A. Rouleau3, Lan Xiong7

1University of Montreal, Canada, 2Centre de recherche, Institut universitaire en santé mentale de Montréal, University of Montreal, Canada, 3Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada, 4Douglas Mental Health University Institute, McGill University, Montreal, Canada, 5Statistical Genetics Research Group, Montreal Heart Institute, Montreal, Canada, 6VA Boston Healthcare, 7Centre de recherche, Institut universitaire en santé mentale de Montréal, Montréal, Canada, Département de psychiatrie, Université de Montréal, Montreal, Canada

 

M48. TRANSCRIPTOMIC SIGNATURES OF SCHIZOPHRENIA REVEALED BY DOPAMINE PERTURBATION OF LYMPHOBLASTOID CELL LINES

Jubao Duan1, Alan Sanders1, Eugene Drigalenko2, Harald H.H Göring3, Pablo Gejman1

1NorthShore University Health System and University of Chicago, 2Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, 3South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, San Antonio, TX

 

M49. GENOME-WIDE POLYGENIC ATLAS OF THE PHENOME IN EMERGING ADULTHOOD: GENETIC OVERLAP OF RISK ACROSS FIVE ANCESTRIES

Anna Docherty1, Arden Moscati1, Jeanne Savage2, Jessica Salvatore2, Megan Cooke1, Fazil Aliev3, Ashlee Moore1, Roseann Peterson2, Alexis Edwards1, Brien Riley2, Daniel Adkins2, Bradley Webb1, Danielle Dick2, Silviu Bacanu2, Kenneth Kendler2

1Virginia Institute for Psychiatric and Behavioral Genetics, 2Virginia Commonwealth University, 3Virginia Commonwealth University and Karabuk University

 

M50. POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF PSYCHOPATHOLOGICAL FEATURES IN A CROSS-DIAGNOSTIC GROUP OF INDIVIDUALS WITH SEVERE MENTAL ILLNESS

Eva Schulte1, Ivan Kondofersky2, Monika Budde3, Kristina Adorjan4, Fanny Aldinger3, Heike Anderson-Schmidt5, Till F. M. Andlauer6, Katrin Gade7, Urs Heilbronner3, Janos Kalman3, Sergi Papiol3, Fabian J. Theis2, Peter Falkai8, Nikola Müller9, Thomas G. Schulze10

1Psychiatrische Klinik des Klinikums der Ludwig-Maximilians Universität München, Munich, Germany, 2Institute of Computational Biology, Helmholtz Zentrum Munich, Germany, 3Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 4Department of Psychiatry and Psychotherapy, 5University Medical Centre Goettingen, 6Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry Munich, 7LMU Munich, Dep. of Psychiatry, 8Molecular and Behavioral Neurobiology, Department of Psychiatry, Ludwig Maximillian University, Munich, Germany, 9Regulatory Networks, Institute of Computational Biology, Helmholtz Zentrum München, 10Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany

 

M51. ESTIMATION OF RISK OF SCHIZOPHRENIA IN FIRST DEGREE RELATIVES AN INDIAN SAMPLE

Triptish Bhatia1, Smita N. Deshpande2, Elizabeth Gettig3, Irving Gottesman4*, Nagendra Narayan Mishra5, Vishwajit Nimgaonkar3

1Indo-US Projects, Dept. of Psychiatry, PGIMER-Dr.R.M.L.Hospital, 2Department of Psychiatry, Dr. RML Hospital, New Delhi,India, 3University of Pittsburgh, 4University of Minnesota, 5Deptartment of Psychology L.S.College, B.R.A.Bihar University

 

M52. ASSOCIATION OF СОМТ, DRD2, MTHFR, MIR-137, DNMT3B POLYMORPHISMS WITH COGNITIVE FUNCTIONING AND SYMPTOM SEVERITY OF SCHIZOPHRENIA PATIENTS

Hanna Kandratsenka1, Anastasia Nesterovich2, Nina Danilenko1, Inessa Halayenka1, Tatyana Shatarnova1, Anna Makarevich1, Oleg Davydenko1

1The Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, 2The Republican Research and Practice Center for Mental Health

 

M53. GENE EXPRESSION ALTERATIONS RELATED TO MANIA AND PSYCHOTIC SYMPTOMS IN PERIPHERAL BLOOD OF PATIENTS WITH A FIRST EPISODE OF PSYCHOSIS

Diogo Marques1, Eduardo Gouvea2, Vanessa Ota1, Cristiano Noto2, Marcos Santoro2, Leticia Spindola2, Patricia Moretti2, Carolina Carvalho2, Gabriela Xavier2, João Sato3, Mirian Hayashi2, Elisa Brietzke2, Ary Gadelha2, Rodrigo Bressan2, Quirino Cordeiro2, Sintia Belangero2

1UNIFESP, 2Federal University of Sao Paulo, 3Federal University of ABC

 

M54. PHARMACO-EPIGENOMIC RESPONSE OF ANTIPSYCHOTIC DRUGS IN THERANOSTICS OF SCHIZOPHRENIA

B Swathy1, Moinak Banerjee1

1Rajiv Gandhi Centre for Biotechnology

 

M55. PHARMACOGENETIC STUDY OF ANTIPSYCHOTIC RESPONSE TO TREATMENT IN MEXICAN PATIENTS WITH SCHIZOPHRENIA: ANALYSIS OF RESPONSE AND RESISTANCE

Raul Escamilla1, Beatriz Camarena2, Ana Fresán2, Ricardo Saracco2, Sandra Hernández2, Alejandro Aguilar2

1Universidad Autónoma de México, 2Instituto Nacional de Psiquiatría Ramón de la Fuente

 

M56. INTEGRATING POLYGENIC ALLELE BURDEN INFORMATION AND PHENOMIC DATA TO CHARACTERIZE COMPLEX DISEASE TRAJECTORIES IN SEVERE MENTAL ILLNESS

Monika Budde1, Ivan Kondofersky2, Kristina Adorjan1, Fanny Aldinger1, Heike Anderson-Schmidt3, Till F. M. Andlauer4, Laura Flatau1, Katrin Gade3, Urs Heilbronner1, Janos Kalman1, Sergi Papiol1, Fabian J. Theis2, Peter Falkai5, Nikola S. Mueller6, Thomas G. Schulze1

1Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 2Institute of Computational Biology, Helmholtz Zentrum Munich, Germany, 3University Medical Centre Goettingen, Germany, 4Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry Munich, Germany, 5Department of Psychiatry, Ludwig Maximillian University, Munich, Germany, 6Regulatory Networks, Institute of Computational Biology, Helmholtz Zentrum Munich, Germany

 

M57. DISC1 GENE NETWORK MUTATIONS IN MAJOR MENTAL ILLNESS

Vishal Sinha1, Alfredo Ortega-Alonso2, Liisa Ukkola-Vuoti3, Iiris Hovatta1, Jari Haukka4, Minna Torniainen5, Sebastian Therman5, Tyrone Cannon6, Jaakko Kaprio1, Jouko Lönnqvist5, Timo Partonen5, Erkki Isometsä5, Tiina Paunio5, Jaana Suvisaari7, William Hennah2

1University of Helsinki, 2Institute for Molecular Medicine Finland, University of Helsinki, 3Institute for Molecular Medicine, 4Hjelt Institute, University of Helsinki, 5National Institute for Health and Welfare, 6Yale University, USA, 7National Institute for Health and Welfare, Helsinki, Finland

 

M58. CROSS-TISSUE EQTL ENRICHMENT OF ASSOCIATIONS IN SCHIZOPHRENIA

Francesco Bettella1, Andrew Brown2, Yunpeng Wang3, Aree Witoelar1, Wesley Thompson4, Andrew Schork4, Anders Dale4, Srdjan Djurovic5, Ole Andreassen1

1University of Oslo, 2University of Geneva, 3NORMENT, 4University of Californa, San Diego, 5Oslo University Hospital

 

M59. POLYGENIC BURDEN ANALYSIS OF LONGITUDINAL CLUSTERS OF QUALITY OF LIFE AND FUNCTIONING IN PATIENTS WITH SEVERE MENTAL ILLNESS

Ashley Comes1, Fanny Aldinger2, Ivan Kondofersky3, Kristina Adorjan4, Heike Anderson-Schmidt5, Till F. M. Andlauer6, Monika Budde7, Katrin Gade4, Urs Heilbronner4, Janos Kalman2, Sergi Papiol4, Fabian J. Theis3, Peter Falkai8, Nikola Müller9, Thomas Schulze4

1Institute of Psychiatric Phenomics and Genomics, 2Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Germany, 3Institute of Computational Biology, Helmholtz Zentrum Munich, Germany, 4Institute of Psychiatric Phenomics and Genomics (IPPG); Ludwig-Maximilians-University Munich, Munich, Germany, 5Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany, 6Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry Munich, 7Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 8Molecular and Behavioral Neurobiology, Department of Psychiatry, Ludwig Maximillian University, Munich, Germany, 9Regulatory Networks, Institute of Computational Biology, Helmholtz Zentrum München

 

M60. POLYGENIC RISK SCORES AND SUBSTANCE ABUSE COMORBIDITY IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDERS

Kristina Adorjan1, Sergi Papiol1, Katrin Gade2, Dörthe Malzahn3, Monika Budde4, Fanny Aldinger1, Janos Kalman1, Urs Heilbronner4, Heike Anderson-Schmidt5, Peter Falkai6, Joel Gelernter7, Thomas Schulze8

1Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Germany, 2LMU Munich, Dep. of Psychiatry, 3Dept. of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 4Institute of Psychiatric Phenomics and Genomics, Medical Center of the University of Munich, 5University Medical Centre Goettingen, 6Molecular and Behavioral Neurobiology, Department of Psychiatry, Ludwig Maximillian University, Munich, Germany, 7Yale Univ. School of Medicine, 8(Institute of Psychiatric Phenomics and Genomics (IPPG); Ludwig-Maximilians-University Munich, Munich, Germany)

 

M61. SHARED GENETIC VARIANTS BETWEEN SCHIZOPHRENIA AND GENERAL COGNITIVE FUNCTION INDICATE COMMON MOLECULAR GENETIC MECHANISMS

Olav B Smeland1, Karolina Kauppi2,3,4, Yunpeng Wang1,2,3, W David Hill5,6, Gail Davies5,6, Oleksandr Frei1, Wen Li1, Jon A Eriksen1, Aree Witoelar1, Francesco Bettella1, Chun C Fan2,7, Wes Thompson8, Schizophrenia Working Group of the Psychiatric Genomics Consortium, neuroCHARGE Cognitive Working Group, Chi-Hua Chen2,3, Srdjan Djurovic9,10, Ian J Deary5,6, Anders M Dale2,3,8,11, Ole A Andreassen1,8
1NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; 2Department of Radiology, University of California, San Diego, La Jolla, CA, United States of America; 3Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, United States of America; 4Department of Radiation Sciences, Umeå University, SE-901 87 Umeå Sweden; 5Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; 6Department of Psychology, University of Edinburgh, Edinburgh, UK; 7Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA; 8Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA, 9Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway; 10NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway; 11Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States of America

 

M62. GABRA2 ASSOCIATION WITH ADDICTION-RELATED ENDOPHENOTYPES IS ENVIRONMENTALLY INFLUENCED

Margit Burmeister1, Elisa Trucco1, Shweta Ramdas1, Stephen Parker1, Mary Heitzeg1, Sandra Villafuerte1, Robert Zucker1

1University of Michigan

 

M63. GENOME WIDE ASSOCIATION RESULTS OF ALCOHOLIC USE DISORDER PATIENTS AND HEALTHY CONTROLS

Swapnil Awasthi1, Eva Friedel1, Hans-Ulrich Wittchen2, Andreas Heinz1, Henrik Walter1, Stephan Ripke3

1Charite Universitatsmedizien, 2Universität Dresden, Dresden, Germany, 3MGH

 

M64. GENOME-WIDE ASSOCIATION ANALYSES REVEAL SNP-BY-CONSUMPTION INTERACTION EFFECTS ON ALT AND AST LEVELS IN ALCOHOL DEPENDENT PATIENTS

Victor Karpyak1, Joanna Biernacka2, Jennifer Geske2, Anthony Batzler2, Daniel Hall-Flavin1, Larissa Loukianova1, Terry Schneekloth1, Michelle Skime1, Mark Frye1, Doo-Sup Choi1

1Mayo Clinic Department of Psychiatry and Psychology, 2Mayo Clinic Department of Health Sciences Research

 

M65. THE EFFECT OF CHRONIC STRESS ON WEIGHT AND HYPOTHALAMIC INSULIN AND MELANOCORTIN 4 RECEPTORS IN YOUNG AND OLD FEMALE MICE

Shikma Keller1, Amit Lotan1, Pavel Tatarskyy1, Gilly Wolf1, Elad Avidan1, Hagar Ben-Ari1, Tzuri Lifschytz1, Liat Shbiro2, Tzlil Tabachnick2, Julia Shaharabany2, Aron Weller2, Bernard Lerer3

1Hadassah Hebrew University Medical Center, Jerusalem, Israel, 2Bar-Ilan University, Ramat-Gan, Israel, 3Biological Psychiatry Laboratory, Hadassah - Hebrew University Medical Center, Jerusalem, Israel

 

M66. NEWBORNS´ TELOMERE LENGTH IS RELATED TO THEIR MOTHERS´ STRESS DURING PREGNANCY AND TO THEIR FATHERS´ LIFE-TIME PSYCHIATRIC DISORDER

Stephanie Witt1, Tabea Send1, Maria Gilles1, Veryan Codd2, Isabell Wolf1, Svenja Bardtke1, Matthew Denniff2, Manfred Laucht1, Nilesh Samani2, Michael Deuschle1, Marcella Rietschel1

1Central Institute of Mental Health, 2University of Leicester

 

M67. THE UNIQUE EVOLUTIONARY SIGNATURE OF AUTISM GENES

Idan Menashe1,  Erez Tsur1, Michael Friger1

1Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel